KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90B1
All Species:
32.73
Human Site:
T709
Identified Species:
51.43
UniProt:
P14625
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P14625
NP_003290.1
803
92469
T709
K
E
D
E
D
D
K
T
V
L
D
L
A
V
V
Chimpanzee
Pan troglodytes
XP_509323
803
92478
T709
K
E
D
E
D
D
K
T
V
L
D
L
A
V
V
Rhesus Macaque
Macaca mulatta
XP_001095189
804
92594
T709
K
E
D
E
D
D
K
T
V
L
D
L
A
V
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P08113
802
92457
T709
K
E
D
E
D
D
K
T
V
M
D
L
A
V
V
Rat
Rattus norvegicus
Q66HD0
804
92752
T709
K
E
D
E
D
D
K
T
V
M
D
L
A
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507634
816
93562
T725
K
E
N
E
E
D
K
T
V
T
D
L
A
V
V
Chicken
Gallus gallus
P08110
795
91537
D705
R
R
V
K
E
N
E
D
D
K
T
V
S
D
L
Frog
Xenopus laevis
NP_001083114
805
92996
T708
K
E
N
E
D
D
Q
T
V
A
D
L
A
V
V
Zebra Danio
Brachydanio rerio
Q90474
725
83300
E637
N
P
A
H
P
I
V
E
T
L
R
E
K
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
E629
N
P
D
H
P
I
V
E
T
L
R
Q
K
A
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
K614
N
P
D
H
A
I
M
K
T
L
R
D
R
V
E
Sea Urchin
Strong. purpuratus
NP_999808
806
92314
T711
E
A
D
A
E
D
E
T
A
K
D
L
A
V
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
D627
K
T
M
E
I
N
P
D
N
G
I
M
E
E
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STX5
823
94185
S732
A
S
D
P
E
D
E
S
V
K
E
T
A
Q
L
Baker's Yeast
Sacchar. cerevisiae
P15108
705
80881
I617
E
I
S
P
K
S
P
I
I
K
E
L
K
K
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
N.A.
N.A.
96.6
95.1
N.A.
90.5
90.5
85
44.2
N.A.
44.2
N.A.
43.2
65.2
Protein Similarity:
100
99.8
99.7
N.A.
N.A.
98.5
97.8
N.A.
95.4
95.1
94.1
62.5
N.A.
61.3
N.A.
61.5
81.3
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
80
0
80
6.6
N.A.
13.3
N.A.
20
53.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
93.3
53.3
93.3
6.6
N.A.
13.3
N.A.
20
73.3
Percent
Protein Identity:
N.A.
46.8
N.A.
47.7
44.4
N.A.
Protein Similarity:
N.A.
63.1
N.A.
67.8
61.2
N.A.
P-Site Identity:
N.A.
13.3
N.A.
26.6
6.6
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
60
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
7
7
0
0
0
7
7
0
0
60
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
60
0
40
60
0
14
7
0
54
7
0
7
7
% D
% Glu:
14
47
0
54
27
0
20
14
0
0
14
7
7
7
14
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% G
% His:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
7
20
0
7
7
0
7
0
0
0
0
% I
% Lys:
54
0
0
7
7
0
40
7
0
27
0
0
20
7
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
40
0
60
0
0
20
% L
% Met:
0
0
7
0
0
0
7
0
0
14
0
7
0
0
0
% M
% Asn:
20
0
14
0
0
14
0
0
7
0
0
0
0
0
0
% N
% Pro:
0
20
0
14
14
0
14
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
0
7
0
7
0
% Q
% Arg:
7
7
0
0
0
0
0
0
0
0
20
0
7
0
7
% R
% Ser:
0
7
7
0
0
7
0
7
0
0
0
0
7
0
0
% S
% Thr:
0
7
0
0
0
0
0
54
20
7
7
7
0
0
0
% T
% Val:
0
0
7
0
0
0
14
0
54
0
0
7
0
60
54
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _